Leafy Greens Alter Gene Expression to Boost Native Immune Response to Fight Disease

Our native immune system is truly amazing in its complexity and ability to continually adapt to an ever changing environment of potential pathogens that could easily colonize and highjack our health if not detected and eradicated quickly. Many people, especially as they age, have a compromised immune response due to negative lifestyle factors including smoking, exposure to environmental and household toxins, stress and especially diet. Up to eighty percent of our initial immune response takes place in our digestive system, and the body uses cues from what we eat to activate essential actions to potential invaders.

Leafy Greens and Crucifers Help Express Digestive Genes that Boost our Innate Immune Response

Consuming a largely processed food diet that is void of nutrients and flavonoids dulls our immune system and dramatically increases the risk of infection, inflammation and chronic disease. A research team from the Walter and Eliza Hall Institutes Molecular Immunology Division in Australia have published the result of their work in the journalNature Immunology that demonstrates how eating your greens may be even more important than previously thought, with the discovery that an immune cell population essential for intestinal health could be controlled by leafy greens in your diet.

A special type of immune cell known as an innate lymphoid cell (ILC) is found throughout the digestive tract and can help protect the body from invading pathogens and also provides a balance between ‘good’ and ‘bad’ bacteria in the intestine. Additionally ILC’s play an important role in controlling food allergies, inflammatory diseases and obesity, and may even prevent the development of bowel cancers. The team discovered that a gene (T-bet) is responsible for producing these critical immune cells and is expressed by signals fed from the foods we eat.

Eat Five to Nine Daily Servings of Leafy Green Vegetables to Fight Chronic Illness

Lead study author, Dr. Gabrielle Belz noted “In this study, we discovered that T-bet is the key gene that instructs precursor cells to develop into ILCs, which it does in response to signals in the food we eat and to bacteria in the gut.” The researchers found that proteins in leafy green cruciferous vegetables interact with surface cell receptors that switch on T-bet to initiate the innate immune response in the digestive tract. Further, the team determined that ILC’s produce a hormone (interleukin-22) that protects the body from invading bacteria and help maintain a healthy environment in the intestine by balancing bacteria levels, and may also help to resolve cancerous digestive lesions.

Dr. Belz concluded“Our research shows that, without the gene T-bet, the body is more susceptible to bacterial infections that enter through the digestive system. This suggests that boosting ILCs in the gut may aid in the treatment of these bacterial infections.” This research helps to explain why a natural food diet consisting of at least five to nine daily servings of vegetables and fruits is essential to promote optimal health and keep our vital immune systems running at peak efficiency to protect our well-being and longevity.

Resveratrol and Nuts Combine to Improve Brain Health and Boost Cognitive Function

Nuts, especially walnuts, almonds and hazelnuts, combined with the potent polyphenol resveratrol team together to improve mood and protect the aging brain to help maintain memory and cognition. Researchers reportingin the New England Journal of Medicinehave found that nuts consumed over a period of years not only help with weight management issues, but also can reduce systemic inflammation to improve spirits and prevent cognitive decline.

Resveratrol has long been associated with brain health. The Journal of Pineal Research reportsthat resveratrol demonstrates anti-aging properties in the brain necessary for energy production and optimal brain function. Combining these two natural agents together as part of your healthy diet can improve mood, help retain memories and preserve youthful thought patterns.

Nuts Improve Mood, Slash Brain Inflammation and Prevent Cognitive Decline

Researchers determined to validate the health-promoting capacity of nuts provided test participants with a diet of walnuts, almonds and hazelnuts for a period of 12 weeks. The volunteers for this study were sex and age-matched individuals given a control diet, and compared to a group not receiving the nut mixture. All participants exhibited symptoms of metabolic syndrome, increasing risk for developing diabetes, heart disease, mood disorders and loss of cognition.

Individuals receiving the nutshad increased levels of serotonin which will help a person feel better and potentially more satisfied and less likely to suffer from depression and poor mood. Additionally, the nut control group demonstrated reduced inflammatory markers from the high polyphenol content of the nuts. This is an important finding, as individuals exhibiting the signs of metabolic syndrome experience the effects of systemic inflammation leading to accelerated brain aging and cognitive decline.

Resveratrol Positively Influences Gene Expression to Restore Mitochondria Function

Mitochondria are the tiny metabolic engines that are responsible for powering each of our trillion or so cells throughout the body. Over time, mitochondria begin to experience loss of function and cellular decline and aging of the cell begin. Mitochondrial regulation is controlled in large part by the ‘longevity’ gene known as Sirt1. Calorie restriction and potent natural nutrients such as resveratrol are known to alter expression of the Sirt1 gene. Researchers have demonstrated that resveratrolis able to restore neural mitochondria function by reviving Sirt1 gene expression, and provides “a potent anti-aging effect within the brain.”

The human brain is a highly metabolic organ, demanding 20% of the total oxygen supply for the body. As such, it is also susceptible to the effects of oxidative stress and free radical damage that cause brain inflammation and advanced signs of aging. Natural nutrients such as resveratrol (25 – 50 mg per day) that cross the blood-brain barrier and foundation monounsaturated fats supplied by most nuts (1 to 2 ounces each day) and seeds protect the brain from damage and dramatically lower the risk of memory loss and cognitive decline.